METHODS AND COMPOSITIONS FOR THE TREATMENT OF BETA-THALASSEMIA
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Dec 22, 2016
app pub date -
May 23, 2016
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Nov 20, 2013
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Methods and compositions for the treatment of β-thalassemia are provided. Methods and compositions restore or increase erythrocyte maturation in individuals afflicted with β-TM by preventing proteolysis of GATA-1 protein. Screening methods for identifying agents which bind heat shock protein 70 (HSP-70) and inhibit HSP-70 α-globin binding, but which allow GATA-1 protein-HSP-1 binding in a manner that prevents GATA-1 proteolysis.
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