CO-EXPRESSION OF MAGNETOTACTIC BACTERIAL GENES AND GENES ENCODING IRON HANDLING PROTEINS IN CELLS

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United States of America Patent

APP PUB NO 20160367706A1
SERIAL NO

15121653

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention provides an improved modified magnetosome that contains more iron therein with the combination of the expressed genes. This is achieved by co-expression of (a) one or more bacterial magnetotactic genes to amplify iron uptake, compartmentalization and biomineralization in cells, with (b) one or more mammalian iron handling proteins that together augment(s) and/or regulate the cells iron pool. As a result, mammalian cells or bacterial cells that are transfected or transformed, respectively, can be more effectively tracked using various imaging technologies.

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Patent Owner(s)

Patent OwnerAddress
MULTI-MAGNETICS INCORPORATEDLONDON ON N6A 4V2

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
FIGUEREDO, Rene London, CA 2 0
GELMAN, Neil London, CA 2 0
GOLDHAWK, Donna E London, CA 4 19
KOROPATNICK, D James London, CA 6 0
PRATO, Frank S London, CA 11 314
THOMPSON, R Terry London, CA 3 31

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