IMPROVED EXTENDED-ACTION TILMICOSIN AND USE THEREOF IN TREATMENT OF BOVINE RESPIRATORY DISEASE COMPLEX (BRD) AND IN DRY COW PERIOD
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United States of America Patent
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Dec 22, 2016
app pub date -
Feb 18, 2015
filing date -
Feb 18, 2014
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Abstract
The invention relates to an improved long-acting or extended-release tilmicosin formulation comprising: tilmicosin phosphate in a concentration between 35 and 50% by weight of the total composition; a first co-solvent in a concentration between 8 and 20% by volume, said first co-solvent being propylene glycol; a second co-solvent in a concentration between 5 and 15% by volume, said second co-solvent being ethyl alcohol; and an emulsifier in a concentration between 1.5 and 15% by weight of the total composition, said emulsifier being poloxamer. The invention also relates to the method for producing said improved long-acting tilmicosin formulation.
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