Method of engineering chemotherapy drug resistant T-cells for immunotherapy
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United States of America Patent
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Oct 27, 2020
Grant Date -
Dec 15, 2016
app pub date -
Nov 21, 2014
filing date -
Nov 22, 2013
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Abstract
The present invention relates to the use of “off-the-shelf” allogeneic therapeutic cells for immunotherapy in conjunction with chemotherapy to treat patients with cancer. In particular, the inventors develop a method of engineering allogeneic T-cell resistant to chemotherapeutic agents. The therapeutic benefits afforded by this strategy should be enhanced by the synergistic effects between chemotherapy and immunotherapy. In particular, the present invention relates to a method for modifying T-cells by inactivating at least one gene encoding T-cell receptor component and by modifying said T-cells to confer drug resistance. The invention opens the way to standard and affordable adoptive immunotherapy strategies for treating cancer.
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