NANOSTRUCTURED COMPOSITION COMPRISING INDOMETHACINE, ITS PHARMACEUTICALLY ACCEPTABLE SALTS AND CO-CRYSTALS AND PROCESS FOR THE PREPARATION THEREOF
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United States of America Patent
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Issued Date -
Dec 15, 2016
app pub date -
Feb 25, 2015
filing date -
Feb 25, 2014
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Abstract
The invention relates to a nanostructured (nanoparticular) composition comprising Indomethacine, its pharmaceutically acceptable salts and co-crystals, processes for the preparation thereof, and compositions useful for pharmaceutical applications. The size of the nanoparticles according to the invention is smaller than 500 nm. Indomethacine (INN) or Indomethacine (USAN, previously BAN) is a non-steroidal anti-inflammatory drug (NSAID), which is used for the treatment of fever, inflammation, spasm, swells and inflammations. The machanism of action of Indomethacine is the inhibition of the synthesis of prostaglandin. It is marketed under the trade names of Indocin, Indocid, Indochron E-R, and Indocin-SR.
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