GENE METHYLATION BASED COLORECTAL CANCER DIAGNOSIS
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United States of America Patent
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Issued Date -
Dec 8, 2016
app pub date -
Dec 19, 2014
filing date -
Dec 20, 2013
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Abstract
The invention provides method of identifying a colorectal cancer in a sample comprising DNA from a subject, determining the methylation status of one or more of the genes selected from BOLL, CDX1, CLIC4, DCC, ESR1, GATA4, GDNF, HLA-G, JUB, MYOD1, NKX2-1, PENK, PITX2, PTGS2, RARB, S100A2, SALL3, SEZ6L, SFRP2, SPARC, TCEB2, TFPI2, THBD, TJP2, TMEFF2, TP53, TWIST1, WT1 or combinations thereof and comparing the methylation status with a control, thereby identifying colorectal cancer DNA in the sample and means for performing the inventive method.
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