NETRIN-1 AND DEPENDENCE RECEPTOR PROTEINS AND METHODS OF USE
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United States of America Patent
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Issued Date -
Dec 8, 2016
app pub date -
Feb 10, 2015
filing date -
Feb 10, 2014
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Abstract
Provided herein are fragments of Netrin-1 proteins, fragments of DCC proteins and NEO1 proteins, and antibodies to epitopes located within the fragments of Netrin-1, DCC, and/or NEO1. Also provided herein are methods for using the fragments and antibodies, including methods for inhibiting binding of Netrin-1 to an UNC5 protein, a DCC protein, and/or a NEO1 protein. Other methods provided herein include inducing apoptosis of a cell, and reducing formation of multimers of Netrin-1 proteins, and treating a subject having a cancer or at risk of having a cancer.
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