Attenuated live vaccine against mycoplasmal pneumonia of swine (MPS) and use thereof

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United States of America Patent

PATENT NO 9849168
APP PUB NO 20160346372A1
SERIAL NO

15113909

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Disclosed are an attenuated live vaccine against mycoplasmal pneumonia of swine (MPS) and use thereof. In the present invention, pathological lung tissues of swine having typical Mycoplasma hyopneumoniae (Mhp) infection and no obvious other pathogenic infections are screened, and subcultured 100 generations in lungs of newborn rabbits; then, Mhp strains are isolated and serially subcultured in a medium; and the Mhp strain AN306 is obtained by screening a plurality of strains, which is deposited with an accession number: CCTCC NO. M2012431. Also disclosed is a live vaccine formulation against MPS prepared on the basis of the attenuated strain and comprising live attenuated strain, a pharmaceutically acceptable carrier or excipient, and optionally an adjuvant and immunogens of other pathogens.

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Patent Owner(s)

Patent OwnerAddress
JIANGSU ACADEMY OF AGRICULTURAL SCIENCESNANJING CITY JIANGSU PROVINCE 210014 ZHONGLING STREET NO 50 NANJING CITY JIANGSU PROVINCE 210014

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bai, Fangfang Nanjing, CN 1 1
Bai, Yun Nanjing, CN 103 312
Feng, Zhixin Nanjing, CN 2 1
Gan, Yuan Nanjing, CN 3 1
Hua, Lizhong Nanjing, CN 1 1
Liu, Dongxia Nanjing, CN 26 269
Liu, Maojun Nanjing, CN 2 1
Shao, Guoqinq Nanjing, CN 1 1
Wang, Haiyan Nanjing, CN 176 991
Wang, Li Nanjing, CN 972 6677
Wang, Zhanwei Nanjing, CN 36 105
Wei, Yanna Nanjing, CN 2 1
Wu, Yuzi Nanjing, CN 2 1
Xiong, Qiyan Nanjing, CN 2 1
Zhang, Daohua Nanjing, CN 12 118

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