Methods and compositions for producing a cell expressing a T cell receptor
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United States of America Patent
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May 19, 2020
Grant Date -
Nov 24, 2016
app pub date -
Jan 28, 2015
filing date -
Jan 29, 2014
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Abstract
Provided is a method for determining a TCR polypeptide chain that can form a TCR specific for a peptide of interest. Also provided are methods and compositions for producing a cell expressing a T cell receptor (TCR) specific for a peptide of interest, methods and compositions for producing a TCR chain nucleic acid and/or pair of TCR chain polypeptides and/or nucleic acids encoding a TCR, a cell population comprising the cell harboring the nucleic acids encoding a TCR obtained by said method, and a method for treating a disorder comprising administering to the subject said cell population.
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