Therapeutic target for musculoskeletal inflammation
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United States of America Patent
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May 23, 2023
Grant Date -
Nov 17, 2016
app pub date -
Jan 14, 2015
filing date -
Jan 14, 2014
priority date (Note) -
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Abstract
A method for monitoring a treatment of a subject having a musculoskeletal disorder is provided. The method includes measuring a first expression level of at least two biomarkers at a treatment site prior to the treatment and measuring a second expression level of the at least two biomarkers at the treatment site after the treatment begins. The method further includes comparing the first expression level of the at least two biomarkers prior to the treatment to the second expression level of the at least two biomarkers post treatment and continuing the treatment, altering the treatment or stopping the treatment based on the comparison. A method of treating a musculoskeletal disorder in a subject is also provided. The method includes removing a aggrecan-hyaluronan matrix from a treatment site in the subject.
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