Deimmunized Serum-Binding Domains and Their Use in Extending Serum Half-Life
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United States of America Patent
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Nov 17, 2016
app pub date -
May 24, 2016
filing date -
May 21, 2011
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Abstract
The present invention is directed to a polypeptide (for example, an antigen-binding molecule) that comprises a polypeptide portion of a deimmunized serum-binding protein capable of binding to said serum protein. The presence of the serum-binding protein extends the serum half-life of the polypeptide, relative to the serum half-life of the polypeptide if lacking the polypeptide portion of the deimmunized serum-binding protein. The invention also pertains to methods and uses that employ such molecules.
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