E-Selectin Antagonists Modified By Macrocycle Formation to the Galactose
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United States of America Patent
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Nov 17, 2016
app pub date -
Jan 15, 2015
filing date -
Jan 17, 2014
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Abstract
Provided herein are glycomimetic E-selectin antagonist compounds of formula (I)) and pharmaceutical compositions comprising at least one of the same. The compounds of the present disclosure include trisaccharide domain mimics comprising at least one macrocycle created through the 2nd and 3rd positions on a galactose within the mimic. Methods are also provided comprising using at least one of such compounds and compositions comprising at least one of the same to treat and/or prevent diseases and disorders treatable by inhibiting binding of an E-selectin to an E-selectin ligand.
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