TARGETED CANCER TREATMENT BY HSP90 INHIBITORS GANETESPIB AND NVP-AUY922

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United States of America Patent

SERIAL NO

15111977

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Abstract

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Methods of treating certain cancers with ganetespib or NVP-AUY922 are disclosed. Also provided are methods of treating cancer wherein the cancer has an FGFR3 mutation and/or a low level expression of UGT1A, and/or a low level expression of UGT1A9 and/or UGT1A10. Also provided are methods of treating cancer with a mutation in FGFR3 and/or a low level expression of UGT1A, and/or a low level expression of UGT1A9 and/or UGTIA10, with ganetespib or NVP-AUY922, in combination with an FGFR3 inhibitor such as BGJ398 and AZD4547.

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Patent Owner(s)

Patent OwnerAddress
SYNTA PHARMACEUTICALS CORPLEXINGTON MA 02421

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Acquaviva, Jaime Ashland, US 4 42
Proia, David Newton, US 28 319

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