NANOPORE SEQUENCING USING REPLICATIVE POLYMERASES AND HELICASES
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United States of America Patent
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Nov 3, 2016
app pub date -
Dec 19, 2014
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Dec 19, 2013
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The present invention relates to a system of nanopore sequencing using nucleic-acid binding proteins wherein the activity of the said protein and the passage of the sequenced nucleic acid molecule through the nanopore are coordinated. In particular, the present invention enables an easy synchronization of nanopore capture with polynucleotide unwinding, which in turn affords an easy way to repeat the whole process of capture and nucleotide characterization.
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