VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders

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United States of America Patent

PATENT NO 10745467
APP PUB NO 20140056892A1
SERIAL NO

13925094

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Abstract

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The present invention relates to a fusion proteins comprising regulatory T cell protein, VISTA (V-domain Immunoglobulin Suppressor of T cell Activation (PD-L3) and an immunoglobulin protein (Ig). The invention also provides the use of VISTA polypeptides, multimeric VISTA polypeptides, VISTA-conjugates (e.g., VISTA-Ig), and VISTA antagonists for the treatment of autoimmune disease, allergy, and inflammatory conditions.

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Patent Owner(s)

  • THE TRUSTEES OF DARTMOUTH COLLEGE; KING'S COLLEGE LONDON

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ceeraz, Sabrina Lebanon, US 10 169
LeMercier, Isabelle Enfield, US 17 186
Lines, Janet London, GB 10 169
Noelle, Randolph J Plainfield, US 80 1338
Nowak, Elizabeth West Lebanon, US 29 549

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