ULTRASOUND-ASSISTED GENE TRANSFER FOR TREATMENT OF XEROSTOMIA
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United States of America Patent
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Nov 3, 2016
app pub date -
May 2, 2016
filing date -
May 1, 2015
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Abstract
Methods and compositions useful for gene transfer into a salivary gland are provided. In certain aspects, methods and compositions useful in the treatment of hyposalivation and/or xerostomia are provided. In particular aspects, methods may include contacting a salivary gland of a subject with a composition containing microbubbles and a non-viral expression vector containing a nucleic acid sequence encoding a water channel, and applying ultrasound to the salivary gland.
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