SYSTEM FOR CO-DELIVERY OF POLYNUCLEOTIDES AND DRUGS INTO PROTEASE-EXPRESSING CELLS
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United States of America Patent
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Oct 27, 2016
app pub date -
Oct 21, 2014
filing date -
Nov 4, 2013
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Abstract
Nanoparticle compositions and pharmaceutical compositions for the delivery of a polynucleotide and a hydrophobic pharmaceutical agent to a cell or tissue that overexpresses a protease are provided. Methods of making such compositions and methods of using such composition to treat a condition associated with a cell or tissue that overexpresses a protease are provided as well. Also provided are kits for use in treating a condition associated with a cell or tissue that overexpresses a protease. The compositions, methods, and kits can be used to selectively deliver anti-tumor agents to cancer cells.
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