IL-6 detection based early diagnosis and prediction of systemic inflammatory response syndrome and sepsis in asymptomatic patients

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United States of America Patent

PATENT NO 11635438
APP PUB NO 20160305957A1
SERIAL NO

15196718

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Methods, systems and kits for the early diagnosis or prediction of systemic inflammatory response syndrome (SIRS) including sepsis in asymptomatic patients, such as patients undergoing a surgical intervention, are provided. Some embodiments include a method and system for the detection or diagnosis of SIRS, or detection or diagnosis of a risk to suffer from or develop SIRS, in an asymptomatic patient comprising the steps of determining the level of IL-6 (or a variant thereof) in a sample from the patient; comparing the level of IL-6 (or a variant thereof) to a reference level; detecting or diagnosing SIRS or diagnosing a risk to suffer from or develop SIRS, wherein the sample is isolated at least 2 times at short intervals and the determining and comparing steps are both repeated for each sample. Also provided are methods, systems and kits for therapy monitoring and mortality prediction.

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Patent Owner(s)

Patent OwnerAddress
MEDIZINISCHE UNIVERSITAT GRAZ8036 GRAZ

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Grueb, Susanne Lucerne, CH 2 8
Neuboeck, Nicole Graz, AT 2 8
Smolle-Juettner, Freyja-Maria Graz, AT 2 8
Weinberg, Annelie-Martina Graz, AT 4 12

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