Substituted aza-bicyclic imidazole derivatives useful TRPM8 receptor modulators
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United States of America Patent
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Aug 1, 2017
Grant Date -
Oct 20, 2016
app pub date -
Jun 29, 2016
filing date -
Mar 5, 2010
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Abstract
The present invention is directed to substituted aza-bicyclic imidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8, including for example, inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold and pulmonary disease aggravated by cold.
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