Affinity Hydrogels for Controlled Protein Release
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United States of America Patent
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Issued Date -
Oct 13, 2016
app pub date -
Oct 27, 2014
filing date -
Jan 23, 2010
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Abstract
The present invention relates to novel porous matrix composites and formulations for controlled protein delivery and the uses therefor. The present invention also provides methods of synthesizing such protein delivery systems. The composites comprise affinity sites embedded in the matrix where the affinity sites are functionalized with nucleic acid aptamers having high affinity for proteins to be released. The aptamers function as binding affinity sites for the proteins to be released. In certain embodiments, release rates are controlled by tuning the binding affinity of the nucleic acid aptamerd to the proteins at a desired level. In yet other embodiments, complementary oligonucleotides that hybridize with the aptamerd are employed to trigger accelerated release of the proteins when desired. Various in situ injectable hydrogels functionalized with aptamers are provided for treating a condition and disease in a subject in need of a therapeutic protein.
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