Generation of heavy-chain only antibodies in transgenic animals

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United States of America Patent

PATENT NO 10638735
APP PUB NO 20160295843A1
SERIAL NO

14962335

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Abstract

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The present invention relates to a method for the generation of VH heavy chain-only antibodies in a transgenic non-human mammal. In particular, the present invention relates to a method for the production of a VH heavy chain-only antibody in a transgenic non-human mammal comprising the step of expressing more than one heterologous VH heavy chain locus in that mammal.

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Patent Owner(s)

Patent OwnerAddress
HARBOUR ANTIBODIES B VGROOTHANDELSGEBOUW CIC ROTTERDAM STATIONSPLEIN 45 UNIT A4 004 ROTTERDAM 3013 AK

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Craig, Roger Kingdon Sandbach, GB 23 642
Grosveld, Franklin Gerardus Rotterdam, NL 26 315
Janssens, Richard Wilhelm Rotterdam, NL 16 260

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