Bispecific antigen-binding constructs targeting HER2

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United States of America Patent

PATENT NO 10947319
APP PUB NO 20160289335A1
SERIAL NO

15036176

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Provided herein are biparatopic antigen-binding constructs that specifically bind HER2. The biparatopic antigen-binding constructs comprise one antigen-binding moiety that binds to ECD2 of HER2, a second antigen-binding moiety that binds to ECD4 of HER2, and an Fc. At least one of the antigen-binding moieties is an scFv. The biparatopic antigen-binding constructs can be used in the treatment of cancer.

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Patent Owner(s)

  • ZYMEWORKS INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dixit, Surjit Bhimarao Richmond, CA 44 1010
Escobar-Cabrera, Eric Vancouver, CA 28 350
Ng, Gordon Yiu Kon Vancouver, CA 30 444
Sanches, Mario Vancouver, CA 20 126
Weisser, Nina E Delta, CA 15 66
Wickman, Grant Raymond Vancouver, CA 15 131

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