METHODS FOR IDENTIFYING MODULATORS OF IL-24 MEDIATED APOPTOSIS AND IMMUNOTHERAPY
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United States of America Patent
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Sep 29, 2016
app pub date -
Jun 8, 2016
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Sep 3, 2013
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Abstract
A method for identifying modulators of Interleukin 24 (IL-24) mediated apoptosis is disclosed. For IL-24 apoptosis to be effective, the cells should express Sigma 1 Receptor (SIR). Additionally apoptosis modulators can be identified by exposing biological cells to test compounds and monitoring for signs of endoplasmic reticulum (ER) stress protein expression; calcium mobilization; or reactive oxygen species (ROS) production.
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