EPITHELIAL-MESENCHYMAL TRANSITION IN CIRCULATING TUMOR CELLS (CTCS) NEGATIVES FOR CYTOKERATIN (CK) EXPRESSION IN PATIENTS WITH NON-METASTATIC BREAST CANCER

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United States of America Patent

APP PUB NO 20160273047A1
SERIAL NO

15033385

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Abstract

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The inventors of the present invention have surprisingly discovered that EGFR expression in nonmetastatic breast cancer patients with CK-negative CTCs could induce EMT process. A simultaneous detection of both EGFR and EMT markers (VIM and Slug) in CTCs might improve prognostic or predictive information in patients with operable breast cancer.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSIDAD DE GRANADAE-18071 GRANADA
SERVICIO ANDALUZ DE SALUD41071 SEVILLA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
GARCÍA, PUCHE José Luis Granada, ES 2 3
LORENTE, ACOSTA José Antonio Granada, ES 4 3
MARCHAL, CORRALES Juan Antonio Granada, ES 10 2
ORTEGA, SÁNCHEZ Francisco Gabriel Sevilla, ES 1 1
SERRANO, FERNÁNDEZ María José Sevilla, ES 4 3

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