PRODUCTS AND METHODS FOR TREATMENT OF FAMILIAL AMYOTROPHIC LATERAL SCLEROSIS

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United States of America Patent

APP PUB NO 20160272976A1
SERIAL NO

14914861

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Abstract

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The present invention relates to RNA-based methods for inhibiting the expression of the superoxide dismutase 1 (SOD-1) gene. Recombinant adeno-associated viruses of the invention deliver DNAs encoding RNAs that knock down the expression of SOD-1. The methods have application in the treatment of amyotrophic lateral sclerosis.

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Patent Owner(s)

Patent OwnerAddress
LUDWIG INSTITUTE FOR CANCER RESEARCH LTDSTADELHOFERSTRASSE 22 ZURICH 8001

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cleveland, Don W La Jolla, CA 27 262
Foust, Kevin Columbus, US 19 183
Kaspar, Brian K Columbus, US 45 382

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