Methods for quantitative amplification and detection over a wide dynamic range
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United States of America Patent
Stats
-
Jan 2, 2018
Issued Date -
N/A
app pub date -
May 23, 2016
filing date -
Jul 21, 2009
priority date (Note) -
In Force
status (Latency Note)
Importance
Abstract
Disclosed are compositions and methods for making differentiable amplicon species at unequal ratios using a single amplification system in a single vessel. The number of differentiable amplicons and their ratios to one another are chosen to span the required linear dynamic range for the amplification reaction and to accommodate limitations of the measuring system used to determine the amount of amplicon generated. Unequal amounts of distinguishable amplicon species are generated by providing unequal amounts of one or more amplification reaction components (e.g., distinguishable amplification oligomers, natural and unnatural NTP in an NTP mix, or the like). The amount of target nucleic acid present in a test sample is determined using the linear detection range generated from detection of one or more amplicon species having an amount within the dynamic range of detection.
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International Classification(s)
- 2016 Application Filing Year
- C12Q Class
- 3975 Applications Filed
- 2340 Patents Issued To-Date
- 58.87 % Issued To-Date
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- 0 Citation Count
- C12Q Class
- 0 % this patent is cited more than
- 7 Age
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