Bio-sensor for the detection of small molecules
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United States of America Patent
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Jul 17, 2018
Grant Date -
Sep 8, 2016
app pub date -
Feb 5, 2014
filing date -
Feb 5, 2013
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Abstract
This present invention provides methods for the detection of small molecules in samples comprising the steps a) coupling a nanoparticle (NP) or microparticle (MP) to an aptamer specific for the small molecule to be detected to form a NP-aptamer conjugate b) contacting the NP-aptamer conjugate with the sample; and c) detecting a change in the size, surface potential, or mobility of the NP-aptamer conjugate, wherein the change is indicative of the presence of the small molecule. The present invention also provides for and a biosensor comprising nanoparticles coupled to aptamers to provide nanoparticle aptamer-conjugates (NP-aptamer).
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