Hemiasterlin derivatives for conjugation and therapy
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United States of America Patent
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Nov 24, 2020
Grant Date -
Sep 8, 2016
app pub date -
Jan 29, 2016
filing date -
Jan 30, 2015
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Abstract
Provided herein are hemiasterlin derivatives, conjugates thereof, compositions comprising the derivatives or conjugates thereof, methods of producing the derivatives and conjugates thereof, and methods of using the derivatives, conjugates, and compositions for the treatment of cell proliferation. The derivatives, conjugates, and compositions are useful in methods of treatment and prevention of cell proliferation and cancer, methods of detection of cell proliferation and cancer, and methods of diagnosis of cell proliferation and cancer. In an embodiment, the hemiasterlin derivatives are according to Formula 1000:
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