CRYSTALLINE SOLVATE FORMS OF CABAZITAXEL

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United States of America Patent

APP PUB NO 20160257663A1
SERIAL NO

15031403

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention relates to new crystalline forms of Cabazitaxel of formula (I). Specifically, the present invention provides four new crystalline solvate forms of Cabazitaxel, designated as form S2 (solvate with 2-methyltetrahydrofuran), form S4 (solvate with tent-butyl acetate), form S5 (solvate with dimethylcarbonate) and form S6 (solvate with N-methyl-2-pyrrolidinone). A further object of the present invention are processes for the preparation of the above mentioned crystalline forms. The crystalline solvate forms of the invention are especially useful for the preparation of Cabazitaxel, Cabazitaxel salts, and polymorphic forms thereof.

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Patent Owner(s)

Patent OwnerAddress
INDENA S P A20139 MILANO

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
CABRI, Walter Milano, IT 98 224
CICERI, Daniele Milano, IT 15 7
DOMENIGHINI, Luca Milano, IT 3 4
GAMBINI, Andrea Milano, IT 14 37
PETERLONGO, Federico Milano, IT 7 5

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