DOSAGE OF NALOXONE
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United States of America Patent
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Issued Date -
Sep 8, 2016
app pub date -
Aug 17, 2015
filing date -
Mar 6, 2015
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Abstract
The present invention relates to a pharmaceutical composition comprising a μ-receptor antagonist as an active substance, wherein the antagonist is prepared in an extended release formulation. The composition is intended for the treatment of patients with opioid-induced constipation, wherein the dosage of the μ-receptor agonist is independent of the opioid dosage. The preferred dosage of the μ-receptor antagonist of the composition is equivalent to a daily dosage of 20-70 mg naloxone.
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