METHOD FOR PREDICTING CLINICAL TOXICITY AND OUTCOME

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United States of America Patent

APP PUB NO 20160251725A1
SERIAL NO

15026957

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A method for determining the sensitivity of a patient with cancer to receptor tyrosine kinase inhibitor therapy is provided. The method comprising screening a nucleic acid sample to determine the identity of at least one single nucleotide polymorphism (SNP) genotype selected from the group consisting of rs1933437, rs1045642, rs1128503, rs2032582 and rs2231142 and any combination thereof; and determining the sensitivity of a patient with renal cancer to receptor tyrosine kinase inhibitor therapy based on the identity of the SNP genotype. The sensitivity is selected from one or more of neutropenia, diarrhea, tumor response, early toxicity-necessitated treatment termination, overall survival and progression-free survival.

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Patent Owner(s)

Patent OwnerAddress
SINGAPORE HEALTH SERVICES PTE LTD31 THIRD HOSPITAL AVENUE #03-03 BOWYER BLOCK C SINGAPORE 168753

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
CHU, Ying Hsia Singapore, SG 1 0
LAI, Johnathan Singapore, SG 1 0
TAN, Min-Han Singapore, SG 16 18
TAN, Puay Hoon Singapore, SG 5 0

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