BRCA2-SPECIFIC MODIFIER LOCUS RELATED TO BREAST CANCER RISK
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United States of America Patent
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Sep 1, 2016
app pub date -
Sep 25, 2015
filing date -
Mar 27, 2013
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Abstract
The present invention relates to novel SNP biomarkers and to panels of biomarkers that may be used in assessing the risk that a patient carrying a BRCA2 mutation will develop breast cancer. It is based, at least in part, on the identification of a SNP located at 6p24 in the human genome which is associated with breast cancer risk in subjects carrying the BRCA2 mutation but not in the general population. In specific non-limiting embodiments, a SNP from the 6p24 region may be used alone or together with one or more breast cancer risk biomarker to evaluate the likelihood that a subject will develop breast cancer.
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