METHODS FOR TREATING CANCERS COMPRISING K-RAS MUTATIONS
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United States of America Patent
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Issued Date -
Aug 25, 2016
app pub date -
Dec 8, 2015
filing date -
Dec 1, 2009
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Abstract
Methods of inhibiting tumor growth, methods of treating cancer, and methods of reducing the frequency of cancer stem cells in a tumor are described. Particularly, the methods are directed to tumors or cancers that comprise a K-ras mutation. The methods described comprise administering a DLL4 antagonist (e.g., an antibody that specifically binds the extracellular domain of human DLL4) to a subject. Related polypeptides and polynucleotides, compositions comprising the DLL4 antagonists, and methods of making the DLL4 antagonists are also described.
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