METHOD OF CONVERTING A CRYSTALLINE COMPOUND TO AN AMORPHOUS COMPOUND, METHOD OF INCREASING THE SOLUBILITY OF A CRYSTALLINE COMPOUND IN A BIORELEVANT FLUID, AND NANOPARTICLES THAT ACHIEVE SUPERSATURATION

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United States of America Patent

SERIAL NO

14952771

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Abstract

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A method of converting a poorly water soluble crystalline compound to an amorphous compound and a method of increasing the solubility of a poorly water soluble crystalline compound in biorelevant fluid at pH 6.5 is disclosed. The method includes dissolving the compound and a polymer in a solvent to form a solution, the polymer being present in the solution in an amount such that after electrospraying the solution the compound is in an amorphous form, electrospraying the solution using an electrospray system, the electrospraying forming nanoparticles, collecting the nanoparticles on a substrate, and removing the nanoparticles in the form of a powder.

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Patent Owner(s)

Patent OwnerAddress
NANOCOPOEIA LLC639 CAMPUS DRIVE NEW BRIGHTON MN 55112

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fu, Huijing Arden Hills, US 2 30
Hoerr, Robert A Shoreview, US 12 424
Lasch, James E Oakdale, US 23 755
Rahi, Mourad F Maple Grove, US 2 30

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