Hypoxia-Targeted Delivery System for Pharmaceutical Agents
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United States of America Patent
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Aug 11, 2016
app pub date -
Oct 21, 2014
filing date -
Oct 21, 2013
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Abstract
Molecular compositions, nanoparticle compositions, and pharmaceutical compositions of the invention provide for the delivery of a polynucleotide to a hypoxic cell or tissue. The compositions can also be used for the delivery a hydrophobic pharmaceutical agent, either alone or in combination with a polynucleotide, to a hypoxic cell or tissue. Methods of making such compositions and methods of using such composition to treat a condition associated with a hypoxic cell or tissue are provided as well. Also provided are kits for use in treating a condition associated with a hypoxic cell or tissue.
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