Gene Expression Profile Breast Tumour Grading
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United States of America Patent
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Aug 4, 2016
app pub date -
Jun 12, 2015
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Jun 12, 2015
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Abstract
We describe a method of assigning a grade to a breast tumour, which grade is indicative of the aggressiveness of the tumour, the method comprising detecting the expression of a gene selected from the genes set out in Table D0 (6g-TAGs) or Table D1 (SWS Classifier 0). We also describe methods of treating patients having a high aggressiveness tumour or a low aggressiveness tumour, by identifying the aggressiveness tumour by obtaining, from a sample of a histological Grade 2 tumour isolated from the patient, gene expression data of BRRN1, AURKA, MELK, PRR11, CENPW and E2F1; assigning a grade to the tumour by applying a class prediction algorithm to the gene expression data, wherein a Grade 3 tumour is classified as a high aggressiveness tumour and a Grade 1 tumour is classified as a low aggressiveness tumour; and specifically treating the patient accordingly.
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