URINE EXOSOME mRNAs AND METHODS OF USING SAME TO DETECT DIABETIC NEPHROPATHY
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United States of America Patent
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Aug 4, 2016
app pub date -
Apr 21, 2016
filing date -
Apr 21, 2016
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Embodiments of the invention relate generally to methods of identifying subjects likely to develop diabetes-associated damage to the nephron, or subjects in the early stages of diabetic nephropathy. In particular, several embodiments relate to quantification of diabetic nephropathy-associated markers by isolating RNA isolated from vesicles from patient urine samples. The levels of the marker in a subject can be compared to levels in a population having normal nephron function and/or used to to track progression of diabetic nephropathy in said subject over time.
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