Biomimetic cell culture substrates
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United States of America Patent
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Mar 9, 2021
Grant Date -
Aug 4, 2016
app pub date -
Feb 3, 2016
filing date -
Feb 3, 2015
priority date (Note) -
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Abstract
Embodiments of the presently disclosed subject matter provide biomimetic cell culture substrates comprising highly tunable patterned polymer nanofiber matrices capable of modulating expression of critical self-renewal factors and markers of cell-cell interaction to maintain stemness of human mesenchymal stem cells in vitro. Embodiments of the presently-disclosed subject matter also provide scalable, highly repeatable methods of making biomimetic cell culture substrates by hot pressing thermoplastic polymer films into femtosecond laser-ablated nanopore molds to form patterned polymer nanofiber matrices on flat thermoplastic substrates.
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