NON-HUMAN MAMMALS FOR THE PRODUCTION OF CHIMERIC ANTIBODIES
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United States of America Patent
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Aug 4, 2016
app pub date -
Apr 11, 2016
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Apr 11, 2016
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Abstract
The invention provides knock-in non-human cells and mammals having a genome encoding chimeric antibodies and methods of producing knock-in cells and mammals. Certain aspects of the invention include chimeric antibodies, humanized antibodies, pharmaceutical compositions and kits. Certain aspects of the invention also relate to diagnostic and treatment methods using the antibodies of the invention.
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