CATALYSED LIGATION OF AZIDES AND ACETYLENES
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United States of America Patent
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Issued Date -
Jul 28, 2016
app pub date -
Mar 30, 2016
filing date -
May 30, 2002
priority date (Note) -
Abandoned
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Abstract
A copper catalyzed click chemistry ligation process is employed to bind azides and terminal acetylenes to provide 1,4-disubstituted 1,2,3-triazole triazoles. The process comprises contacting a solution of an organic azide and a terminal alkyne with a source of catalytic Ru ion to form a 1,4-disubstituted 1,2,3-triazole.
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