METHOD AND APPARATUS FOR ISOLATION, CAPTURE AND MOLECULAR ANALYSIS OF TARGET PARTICLES
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United States of America Patent
Stats
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N/A
Issued Date -
Jul 21, 2016
app pub date -
Aug 28, 2014
filing date -
Aug 29, 2013
priority date (Note) -
Published
status (Latency Note)
Importance
Abstract
Methods and apparatuses for target particle separation and isolation are disclosed. The apparatuses are flow chambers that include an infusion port configured to introduce a sample, and an elution flow port configured to receive an elution buffer. The flow chamber also includes an electrode coupled to a floor of the flow chamber, wherein the electrode includes at least a first zone with a first inter-electrode pitch and a second zone with a second inter-electrode pitch. The first zone generates a first electric field and the second zone generates a second electric field of a different magnitude than the first electric field when an electric signal is applied. The first electric field and the second electric field separate the target particle from the fluidic suspension via dielectrophoresis. The flow chamber also includes a waste disposal port that discharges the waste material, and a collection port configured that collects a target particle enriched sample.
First Claim
Other Claims data not available