Antisense Oligonucleotides Against Neutral Sphingomyelinase and Neutral Sphingomyelinase Inhibitor GW4869 for Degenerative Neurological Disorders

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United States of America Patent

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15017236

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Abstract

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Alzheimer's disease (AD) is the most common human neurodegenerative disease of the CNS resulting in progressive neuronal death and memory loss. Despite intense investigations, no effective therapy is available to stop its onset or halt its progression. It was discovered that antisense oligonucleotide against neutral sphingomyelinase and GW4869, a chemical inhibitor of neutral sphingomyelinase, inhibit activation of glial cells and protect neurons in AD cell culture and animal models. These results suggest the following new treatment options for AD patients: Antisense oligonucleotide against neutral sphingomyelinase and GW4869.

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RUSH UNIVERSITY MEDICAL CENTERCHICAGO IL 60612

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  • 2016 Application Filing Year
  • A61K Class
  • 19101 Applications Filed
  • 13019 Patents Issued To-Date
  • 68.16 % Issued To-Date
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Inventor Name Address # of filed Patents Total Citations
Pahan, Kalipada Skokie, US 38 15

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