IMMUNORECEPTOR MODULATION FOR TREATING CANCER AND VIRAL INFECTIONS

Number of patents in Portfolio can not be more than 2000

United States of America Patent

APP PUB NO 20160208000A1
SERIAL NO

14913348

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A method of reducing or relieving immune inhibition in a mammal includes the step of at least partly inhibiting or reducing CD96 activity in one or more cells of the mammal to thereby relieve immune inhibition and/or enhance or restore immune surveillance in the mammal. Typically, inhibiting or reducing CD96 activity does not include, or depend upon, killing of CD96-expressing cells in the mammal. The method relieves immune inhibition and/or enhances or restores immune surveillance in the mammal to thereby treat or prevent cancer or cancer metastasis and/or a viral infection in the mammal. Also provided is a method of screening, designing, engineering or otherwise producing a CD96-inhibitory agent that relieves immune inhibition and/or enhances or restores immune surveillance in a mammal. Typically, the CD96-inhibitory agent is an antibody or antibody fragment.

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Patent Owner(s)

Patent OwnerAddress
THE COUNCIL OF THE QUEENSLAND INSTITUTE OF MEDICAL RESEARCHHERSTON QUEENSLAND 4006

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Smytbe, Mark Milton, AU 1 4

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