Zinc finger linker (ZnFL) antibody
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United States of America Patent
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Aug 11, 2020
Grant Date -
Jul 14, 2016
app pub date -
Dec 28, 2015
filing date -
Dec 29, 2014
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Abstract
The present invention provides a purified antibody that recognizes the conserved zinc fingers linker region (ZnFL) in multiple KRAB-ZNF. The purified antibody recognizes at least one of a conserved zinc finger linker sequence of TGEKPY (SEQ ID NO: 1), TGEKPYK (SEQ ID NO: 2), and TGEKPYE (SEQ ID NO: 3). A method of treating a patient having cancer comprising administering an effective amount of a purified antibody recognizing at least one of a conserved zinc finger linker sequence of TGEKPY (SEQ ID NO: 1), TGEKPYK (SEQ ID NO: 2), and TGEKPYE (SEQ ID NO: 3) is set forth. A diagnostic kit and an affinity matrix detecting one of these conserved zinc finger linker sequences are disclosed. A method of detecting cancerous cells comprising subjecting a cancerous cell to a purified pan-ZNF specific antibody is provided. An antigen is provided that binds to a purified zinc finger linker antibody sequence selected from the group consisting of: SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO: 7, SEQ ID NO:8, and SEQ ID NO:9.
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