USES OF PHOSPHOLIPID CONJUGATES OF SYNTHETIC TLR7 AGONISTS
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United States of America Patent
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app pub date -
Aug 14, 2014
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Aug 16, 2013
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Abstract
The invention provides uses for phospholipid conjugates of TLR agonists as enhancers of an innate immune response. Specifically, purine derivatives which are conjugated to a phospholipid or an analog thereof are disclosed as having activity as TLR7 agonists, capable of inducing an innate immune response upon administration in an effective amount to a subject. The phospholipid moiety of the TLR7 agonist contains one or more alkyl ether or ester moieties.
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