METHODS OF TREATING BRAIN ISCHEMIA OR HYPOXIA
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United States of America Patent
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Issued Date -
Jul 14, 2016
app pub date -
Aug 18, 2015
filing date -
Jan 8, 2015
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Methods of treating brain ischema or hypoxia by using an inhibitor of cysteine-glutamate transporter (i.e. system xc−) is provided. The inhibitor includes sorafenib and a derivative thereof, erastin, and suifasalazine. These inhibitors can effectively decrease a concentration of extracellular glutamate, so that excitotoxicity to central nervous system (CNS) and a cortical infarct volume in brains can be reduced.
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