Purification of chimeric FVIII molecules

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United States of America Patent

PATENT NO 10947269
APP PUB NO 20160185817A1
SERIAL NO

14910555

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Abstract

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The invention is directed to methods of purifying a chimeric protein comprising subjecting the chimeric protein to a factor VIII-specific affinity chromatography, and subjecting the chimeric protein to an AEX chromatography; wherein the chimeric protein comprises a factor VIII protein or a fragment thereof. The chimeric protein purified by the present methods shows improved factor VIII activity.

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Patent Owner(s)

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BIOVERATIV THERAPEUTICS INC225 SECOND AVENUE WALTHAM MA 02451

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Acosta, Marisol Worcester, US 2 9
Kole, Anxhela Quincy, US 2 9
Kulman, John Belmont, US 37 242
Zhu, Lily Belmont, US 145 647

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