METHOD FOR THE PURIFICATION OF EPOTHILONES VIA CRYSTALLIZATION
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United States of America Patent
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Jun 30, 2016
app pub date -
Aug 18, 2014
filing date -
Aug 18, 2014
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Abstract
The present invention provides a new method of separating epothilones from one another that can be used on an industrial scale for the selective enrichment of epothilone and to provide a crystalline solid of enhanced purity, which can be used for the production of pharmaceutical preparations without using normal or reverse-phase chromatography or any energy input via distillation apparatus, wherein the new method comprises the steps:
- a. dissolving a crude containing epothilones in an nonpolar protic solvent,b. adding an amount of a polar protic anti-solvent to form a slurry,c. isolating a crystalline solid from the slurry.
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