LOW SWELL TISSUE ADHESIVE AND SEALANT FORMULATIONS
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United States of America Patent
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app pub date -
Jul 28, 2014
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Jul 29, 2013
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Abstract
A hydrogel tissue adhesive formed by reacting an aldehyde-functionalized dextran containing pendant aldehyde groups with a multi-arm polyethylene glycol amine is described. The hydrogel exhibits little to no swell upon exposure to physiological conditions. The hydrogel may be useful as a tissue adhesive or sealant for medical applications that require a low swell hydrogel to inhibit complications, such as fibrosis, including scar formation or surgical adhesions.
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