E. COLI MEDIATED siRNA SILENCING OF AVIAN INFLUENZA IN CHICKENS

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United States of America Patent

APP PUB NO 20160177296A1
SERIAL NO

14604252

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Abstract

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Product, and associated methods are described for the delivery of one or more small interfering RNAs (siRNAs) to an avian cell using a nonpathogenic bacterium for the prevention or treatment of Avian Influenza Virus (AIV). The siRNA is complementary to an mRNA of the AIV NP or PA sequence. In challenge studies with chickens, the siRNA is shown to prevent the onset of clinical symptoms or reduce the severity of disease, including reducing viral titers or virus shedding.

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Patent Owner(s)

Patent OwnerAddress
COLORADO STATE UNIVERSITY RESEARCH FOUNDATION2537 RESEARCH BLVD SUITE 200 FORT COLLINS CO 80526

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Linke, Lyndsey M Windsor, US 7 18
Salman, Mo D Fort Collins, US 2 2
Wilusz, Jeffrey Fort Collins, US 7 21

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